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Donald R. Smith
Professor of Environmental Toxicology
B.A, University of California, Santa Cruz
M.A., California State University, San Francisco (Moss Landing)
Ph.D., University of California, Santa Cruz
Office: 442 PSB, Office Hours: By
Appointment
Email: smith@metx.ucsc.edu
Office Phone: (831) 459-5041
Lab Phone:
(831)459-4571
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Research Group: Smith
Lab
Molecular, cellular, and organismal responses to metals. Neurotoxicology and therapeutic treatment of metal poisoning.
Research
Our research seeks to understand the mechanistic basis and functional outcomes of metal toxicity. Our efforts have centered around the effects of lead in model systems and humans, with emphasis on the study of therapeutic treatments for lead poisoning. We have also become quite interested in the neurotoxicology of manganese and other redox active metals, and how they contribute to neurologic disease. Our research is both integrative and interdisciplinary. We use an array of analytical, biochemical, and molecular techniques to investigate basic mechanisms of action at the biochemical/molecular level, and the functional outcomes at the organ and whole organism level.
Examples of current research topics in our lab include:
- The molecular targets, biochemical mechanisms, and functional
outcomes
of manganese neurotoxicity.
- Exposure pathways and neurotoxic actions of lead; use of stable lead isotopic tracers and mass spectrometry to study lead metabolism and the physiologic basis of individual susceptibility to lead uptake and retention.
- The efficacy of therapeutic treatments to alleviate
metal toxicity.
- Wildlife toxicology.
Selected Publications:
Jursa, T., and Smith, D.R. 2009. Ceruloplasmin alters the tissue disposition and neurotoxicity of manganese, but not its loading onto transferrin. Toxicol Sci. 2009 Jan;107(1):182-93.
Lamadrid-Figueroa H, Téllez-Rojo MM, Hernández-Avila M, Trejo-Valdivia B, Solano-González M, Mercado-Garcia A, Smith D, Hu H, Wright RO. 2007. Association between the plasma/whole blood lead ratio and history of spontaneous abortion: a nested cross-sectional study. BMC Pregnancy Childbirth. Sep 27:7-22.
Beaudin, S., Stangle, D., Smith, D.R., Levitsky, D., and Strupp, B. 2007. Succimer chelation normalizes reactivity to reward omission and errors in lead-exposed rats. Neurotoxicology and Teratology 29:188-202.
Gwiazda, R., Lucchini, R., and Smith, D.R. 2007. Adequacy and consistency of animal studies to evaluate the neurotoxicity of chronic low level manganese exposure in humans. J. Toxicol. Env. Health, Part A 70:594-605.
Smith, D.R., Gwiazda, R., Roels, H., Park, R., Bowler, R., Apostoli, P., and Lucchini, R. 2007. Biomarkers of Mn exposure across animal model and human occupational exposures. Am. J. Ind. Med. 50(11):801-11.
Lamadrid-Figueroa, H, Téllez-Rojo, M., Hernández-Avila, M., Trejo-Valdivia, B., Solano-González, M., Mercado-Garcia, A., Wright, R., Smith, D.R., and Hu H. 2007. Association between the plasmatic fraction of lead and history of abortion in Mexican women. Human Repro. 27;7(1):22 .
Finkelstein, M., Grasman, K., Croll, D., Tershy, B., Keitt, B., Jarman, W., and Smith, D.R. 2007. Contaminant-associated alteration of immune function in Black-footed albatrosses (Phoebastria nigripes) in the North Pacific. Environ. Toxicol. Chem.26(9):1896-903.
Crooks, D., Welch, N., and Smith, D. 2007. Low-level manganese exposure alters glutamate metabolism in GABAergic AF5 cells. Neurotoxicology 28(3):548-54.
Crooks, D., Ghosh, M., Braun-Sommargren, M., Rouault, T., and Smith, D.R. 2007. Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. J. Neurosci. Res. 85:1797-1809.
Bowler, R., Roels, H., Nakagawa, S., Drezgic, M., Diamond, E., Park, R., Koller, W., Bowler, R., Mergler, D., Smith, D., and Gwiazda, R., and Doty, R. 2007. Dose-effect relations between manganese exposure and neurological, neuropsychological, and pulmonary function in confined space bridge welders. J. Occup. Environ. Med. 64(3):167-77.
Stangle, D., Smith, D.R., Beaudin, S., Strawderman, M., Levitsky, D., and Strupp, B. 2007. Succimer Chelation Improves Learning, Attention and Arousal Regulation in Lead-Exposed Rats but Produces Lasting Cognitive Impairment in the Absence of Lead Exposure. Env. Heatlh Perspect. 115(2):201-9.
Kwik-Uribe, C. and Smith, D.R. 2006. Temporal responses in the disruption of iron regulation by manganese. J. Neurosci. Res. 83: 1601-1610.
Finkelstein, M., Keitt, B.S., Croll, D.A., Tershy, B., Jarman, W.M., Rodriguez-Pastor, S., Anderson, D.J., Sievert, P.R., Smith, D.R. 2006. Albatross species demonstrate regional differences in North Pacific marine contamination. Ecol Appl. 16(2):678-86.
Hu, H., Téllez-Rojo, M., Bellinger, D., Smith, D.R., Ettinger, A., Lamadrid-Figueroa, H., Schwartz, J., Schnaas, L., Mercado-García, A., and Hernández-Avila, M. 2006. Fetal lead exposure at each stage of pregnancy as a predictor of infant mental development. Env. Health Perspect. 114(11):1730-5.
Church, M., Gwiazda, R., Risebrough, R.W., Sorenson, K., Chamberlain, C.P., Aarry, S., Heinrich, W., Rideout, B., Smith, D.R. 2006. Ammunition is the principal source of lead accumulated by california condors re-introduced to the wild. Environ. Sci. Technol. 40:6143-6150.
Reaney, S. Bench, G., and Smith, D. 2006. Brain accumulation and toxicity of Mn(II) and Mn(III) exposures. Tox. Sci. 93(1), 114–124.
Sanchez, J., Crooks, D., Lee, C. , Schoen, C., Amable, R., Zeng, X., Florival-Victor, T., Morales, N., Truckenmiller, M., Smith, D.R., and Freed, W. 2006. GABAergic lineage differentiation of AF5 neural progenitor cellsin vitro. Cell Tiss. Res. 324:1-8.
Church, M., Gwiazda, R., Risebrough, R.W., Sorenson, K., Chamberlain, C.P., Aarry, S., Heinrich, W., Rideout, B., Smith, D.R. 2006. Ammunition is the principal source of lead accumulated by california condors re-introduced to the wild. Environ. Sci. Technol. (in press, web release August 30th, 2006).
Gwiazda, R., Lucchini, R., and Smith, D.R. 2006. Adequacy and consistency of animal studies to evaluate the neurotoxicity of chronic low level manganese exposure in humans. J. Tox. Env. Health (in press).
Reaney, S. Bench, G., and Smith, D. 2006. Brain accumulation and toxicity of Mn(II) and Mn(III) exposures. Tox. Sci. (in press).
Lamadrid-Figueroa, H., Téllez-Rojo, M., Hernández-Ávila, M., Solano-González, M., Mercado-García, A., Smith, D., Hu, H. 2006. Biomarkers of fetal and maternal lead exposure and history of abortion in women in Mexico City. J. Toxicol. Env. Health (in press).
Sanchez, J., Crooks, D., Lee, C. , Schoen, C., Amable, R., Zeng, X., Florival-Victor, T., Morales, N., Truckenmiller, M., Smith, D.R., and Freed, W. 2006. GABAergic lineage differentiation of AF5 neural progenitor cellsin vitro. Cell Tiss. Res. 324:1-8.
Park, R., Bowler, R., Eggerth, D, Diamond, E., Spencer, K., Smith, D.R., and Gwiazda, R. (2006). Issues in neurological risk assessment for occupational expsoures: The Bay Bridge Welders. Neurotoxicology 27: 373-384.
Kwik-Uribe, C. and Smith, D.R. 2006. Temporal responses in the disruption of iron regulation by manganese. J. Neurosci. Res. 83: 1601-1610.
Reaney, S.H. and Smith, D.R. 2005. Manganese oxidation state mediates toxicity in PC12 cells. Toxicol. Appl. Pharmacol. 205(3):271-281.
Gwiazda, R., Campbell, C., and Smith, D.R. (2005). A non-invasive approach to estimate the bone lead contribution to blood in children: Implications for assessing the efficacy of lead abatement. Environ. Health Perspect.113:104-110.
Chamberlain, C.P., Waldbauer, J.R., Fox-Dobbs, K., Newsome, S., Koch, P., Smith, D.R., Church, M., Chamberlain, S., Sorenson, K., and Risebrough, R. 2005. Pleistocene to recent dietary shifts in California condors. PNAS, 102:46, 16707–16711.
Reaney, S.H. and Smith, D.R. 2005. Manganese oxidation state mediates toxicity in PC12 cells. Toxicol. Appl. Pharmacol. 205(3):271-281.
Gwiazda, R., Campbell, C., and Smith, D.R. (2005). A non-invasive approach to estimate the bone lead contribution to blood in children: Implications for assessing the efficacy of lead abatement. Environ. Health Perspect.113:104-110.
Chamberlain, C.P., Waldbauer, J.R., Fox-Dobbs, K., Newsome, S., Koch, P., Smith, D.R., Church, M., Chamberlain, S., Sorenson, K., and Risebrough, R. 2005. Pleistocene to recent dietary shifts in California condors. PNAS, 102:46, 16707–16711.
Tellez-Rojo, M.M., Hernandez-Avila, M., Lamadrid-Figueroa, H., Smith D., Hernandez-Cadena, L., Mercado, A., Aro, A., Schwartz, J., and Hu, H. 2004. Impact of bone lead and bone resorption on plasma and whole blood lead levels during pregnancy. Am J Epidemiol. 160:668-678.
Juarez-Perez, C.A. , Aguilar-Madrid, G., Smith, D.R., Lacasana-Navarro, M., Tellez-Rojo, M., Piacitteli, G., Hu, H., and Hernandez-Avila, M. 2004. Predictors of plasma lead among lithographic print shop workers in Mexico City . Am. J. Ind. Med. 46:245-252.
Stangle, D, Strawderman, M., Smith, D., Kuypers, M., and Strupp, B. (2004). Reductions in blood lead overestimate reductions in brain lead after repeated succimer regimens in a rodent model of childhood lead exposure. Enviorn. Health Perspect. 112:302-308.
Gwiazda, R., Squibb, K., McDiarmid, M., and Smith, D.R. 2004. Detection of depleted uranium DU) in urines of veterans from the 1991 Gulf War. Health Physics 86(1):12-8.
Tellez-Rojo, M.M., Hernandez-Avila, M., Lamadrid-Figueroa, H., Smith D., Hernandez-Cadena, L., Mercado, A., Aro, A., Schwartz, J., and Hu, H. 2004. Impact of bone lead and bone resorption on plasma and whole blood lead levels during pregnancy. Am J Epidemiol. 160:668-678.
Stangle, D, Strawderman, M., Smith, D., Kuypers, M., and Strupp, B. (2004). Reductions in blood lead overestimate reductions in brain lead after repeated succimer regimens in a rodent model of childhood lead exposure. Enviorn. Health Perspect. 112:302-308.
Gwiazda, R., Squibb, K., McDiarmid, M., and Smith, D.R. 2004. Detection of depleted uranium DU) in urines of veterans from the 1991 Gulf War. Health Physics 86(1):12-8.
Kwik-Uribe, C., Reaney, S., Zhu, Z., and Smith, D. 2003. Alterations in the Cellular Abundance of IRP-Dependent Proteins and the Size of the Labile Iron Pool as a Consequence of In Vitro Manganese Exposure in Undifferentiated PC12 Cells. Br. Res., 973:1-15.
Finklestein, M., Grasman, K., Croll, D., Tershey, B., and Smith, D. 2003. Immune Function of Cryopreserved Avian Peripheral White Blood Cells: Potential Biomarkers of Contaminant Effects in Wild Birds. Arch. Environ. Contam. Toxicol. 44:502-509.
Finklestein, M., Gwiazda, R., and Smith, D. 2003. Lead poisoning of seabirds: Environmental risks from leaded paint at a decommissioned military base. Env. Sci. Tech. 37:3256-3260.
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